Thursday 30 January 2020

Many facets of the Corona Virus outbreak


With every passing day the number of infections and deaths due to the novel Corona Virus (nCV) are steadily mounting. At the time of writing, the official reported infections reached 5974 and killed 132 people in China.

On December 31st WHO alerted the World of the growing number of severe pneumonia cases in Wuhan City, Hubei province. By January 7th Chinese authorities reported that the infection is caused by Corona virus which belongs to the family of SARS (Severe Acute Respiratory Syndrome) and MERS (Middle East Respiratory Syndrome) and called it nCov-2019 (1). SARS caused major health emergency in China in Nov 2012-March 2013 killing 800 people across the World and entailing financial losses worth $50 billion. nCoV and SARS have emanated from China. Logically, people have started drawing parallels between the two. The mortality rate of SARS has been 15% as opposed to less than 3% of nCoV, thus far. Going by these numbers some people have downplayed the nCoV threat. Given the vast spread of nCoV and number of infections crossing SARS, it is causing intense concern. Baring Africa and South America the virus has now spread to all continents.

Epidemiological investigations of Chinese researchers revealed that nCoV has “close range droplet transmission”. Meaning, the virus spreads through the sneezing or coughing of the infected person to anyone who comes in contact indicating that nCoV has high pandemic risk. Also, SARS with incubation period of 2-7 days wasn’t contagious when someone had no symptoms, while nCoV with an incubation period of 10-14 days don’t show symptoms but remains contagious. It means the patient would serve as a hidden carrier. Implying that rigorous control and prevention strategies can curtail spread of the virus shifting. As a result, the onus is now on the public health care agencies to curb the rapid transmission.

Consequently, China imposed lock down on Wuhan city and 12 other cities, identified as the epicentre of infection. Imposed ban on wild life trade as Wuhan seafood and animal market was believed to have been the starting point of infection. But even before lockdown, several people left the city on the eve of Lunar New Year increasing the prospect of spread of infection. Intriguingly, despite the impending pandemic threat, WHO cautioned of high alert and refrained from declaring it as a health emergency. WHO’s callous approach has only strengthened of popular perception of China high-level penetration of UN agencies and its growing influence in the intergovernmental organisations. This inadvertently brought to fore appointment of President Xi’s wife Peng Liyuan as WHO good will ambassador for tuberculosis and HIV in 2011 and WHO rescinding invitation to Taiwan for the World Health Assembly (WHA) in 2018. The island attended WHA meet from 2009 and 2016 when the Taiwanese regime during that period kow-towed to mainland China.  While the Tsai-Ing who challenged the Beijing’s authority was denied a invitation at the World forum.

WHO defended its position stating that through unprecedented quarantining of 20 million people China has contained spread of virus. It also indicated that so far beyond China, there were no reports of human to human spread. As the number of infections, increased, WHO designated Corona virus as “public health emergency of international concern” and stopped short of saying it as global emergency which would trigger a concerted global action. People severely criticised WHO’s cautious approach which reminded them of its tepid response towards Ebola outbreak in 2014 which claimed 11,300 lives by the time it ended in 2016 (2).

Sharing his concerns about the origins of nCoV, with The Washington Post, an Israeli biowarfare analyst, Dany Shahom said the virus might have originated from the Wuhan Institute of Virology, a laboratory working on deadly viruses (3). China is known to be working on the Biological Weapons under dual military-civilian program. While the institute is under Chinese Academy of Sciences, a unit, Wuhan National Biosafety Laboratory at the institute engaged in research in Ebola, Nipah and Crimean-Congo haemorrhagic fever viruses is known to have links with PLA (Peoples Liberation Army) and BW (Biological Weapons)-related elements within Chinese defence establishment. It no secret that there exists no demarcation between the military and civilian institutions in China, research involving dangerous pathogens have imbued geopolitical implications as well. This observation will raise hackles in diplomatic circles as well.

Wuhan National Biosafety Laboratory was certified a BSL-4 (Bio Safety Laboratory) a biocontainment of highest safety capable of handling level 4 pathogens in January 2017. Chinese Academy of Sciences approved the construction of the lab in 2003. In the aftermath of the SARS infection, underscoring the importance of tackling any health emergence with the assistance from France, Beijing managed to finish the construction by 2015. Scientists trained in Lyon for years to work on these organisms. Since 2017, the lab started working on BSL-3 organisms and steadily expanded it to BSL-4 research on primates which are abundant in China. Japan has been the first Asian country to have biocontainment laboratory in 1981. Later Taiwan built two such laboratories. Despite concerns of gigantic proportions on humanity from virulent pathogens, Western countries like the US and France are racing to build more laboratories. China which regards these kinds of developments as badge of honour, not be left behind considered BSL-4 facility as a status symbol.

Western scientists have expressed worries about Chinese lab since SARS has escaped containment lab in Beijing multiple times. China’s record in handling these zoonotic virus (virus which spread from animals to humans) has been poor. Mincing no words, Tim Trevan founder of CHROME Biosafety and Biosecurity Consulting in Damascus, Maryland told Nature that “an open culture is important for maintaining BSL-4 containment labs” (4). Transparency and openness in sharing information are crucial. These aspects are lacking in China. Further the regulations in the use of animal for testing these pathogens are less stringent. Instead of working towards bringing more transparency, stringency in use of primates for experiments and openness in science, China is expanding the network. It has built such dual facility containment labs in Harbin, Beijing, Kunming and awaiting accreditation. Wuhan Biosafety Laboratory is just 20 miles from the Wuhan seafood markets and the scientific community believes that the virus must have mutated, leaked out of the lab and through animal-human contact became epicentre of the virus. China’s poor compliance record in toxin research and development is only adding more weight to such speculations. While the Chinese propaganda machinery is trying to present the outbreak of the contagion as a western ploy, there are no takers for this theory.

While the World is in awe at the scale and speed Chinese government is mobilising resources to spread the contagion, 56 million Chinese who are under lockdown are now complaining about the restrictions. Wuhan’s health system is showing cracks. The Mayor is blaming Beijing for downplaying the threat and censoring information. Hospitals are running out of supplies. The façade of the party’s infallibility and efficiency to handle any situation is now slowly falling apart.  Cracks within the system are showing up. People are questioning the omnipotence of the government. Given China’s opaque style of functioning, experts are suspecting underreporting. Countries are now evacuating their citizens due to major health risks. Neighbouring country (read as Malaysia) is taking a dig at the Chinese diverse food habits as well.

China disclosed about SARS three months after its outbreak. People are suspecting similar coverup even now. SARS hit China when its economy is at its peak and hence the country bounced back to normalcy without a hitch. Chinese economy is currently going through a slowdown. The restrictions on travel and trade together with lockdown and suspension of regular activity will have a major toll on economy. Oil prices fell due to a dip in demand. Stock markets across the globe are witnessing a slump. Tourism has plummeted. China accounts for one third of the global trade and the extension of the Lunar New Year Holidays have bolstered fears of the Corona epidemic. The tremors of trade slump are now felt by global markets.

Scientists in Hongkong are reported to have isolated the virus and developed a vaccine (5). But testing in animals is going to take time. Australian scientists have recreated the virus. This can help in early diagnosis and vaccine development (6). US and China have intensified their efforts as well. Much awaited Sino-US trade deal is believed to offered a much-needed boost to the Chinese economy. But the Corona virus outbreak has not only hit the economy, it exposed the fissures in Chinese governance and the invincibility of Xi. Above all, now Beijing’s biowarfare program is under scrutiny as well.


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